Variations in indexation of left atrial volume across different races

BackgroundLeft atrial volume (LAV) has prognostic value. Guidelines propose indexation to body surface area (BSA), however studies demonstrate this can overcorrect for size. Limited investigate across different ethnicities. We sought evaluate the effect of ethnicity on indexation.MethodsUsing data from World Alliance Societies Echocardiography (WASE) cohort, healthy subjects were classified by race as White, Black, Asian, or Other. Biplane LAV was indexed traditional isometric measurements (BSA, height, weight, ideal weight (IBW) and IBW derived BSA (IBSA)), well previously-derived allometric height exponents (2.7 1.72). Additionally, an our cohort (linear regression logarithmic transformation = a(height)b) 1.87. All indices then assessed using Spearman correlation, with a good index retaining correlation LAV/index raw (r∼1), while avoiding overcorrection (r∼0).ResultsThere 1366 (White: 524, Black: 149, Asian: 523, Other: 170; median age 44 years, 653 females (47.8%)). In entire group, BSA, IBSA, height1.87 height1.72 performed (r > 0.9 all), minimising size, < 0.1 all). On race-specific analysis, overcorrected size in White population 0.128). Height1.72 minimised all populations ≤ races).ConclusionDespite normal BMI, there still disparity races. Allometric indexation, particularly height1.72, is possible solution, although further validation BMI extremes are required.